Hypothyroidism presents with which of the following?

• A. Excess thyroid secretion causing weight loss.
• B. Cushing's syndrome.
• C. Deficiency of thyroid secretion causing fatigue, cold intolerance, and low metabolic rate.
• D. Hyperprolactinemia.

Answer: (C)

Hypothyroidism occurs when the thyroid gland doesn’t produce enough hormones, so the body's metabolism slows down. That slowdown shows up as fatigue, cold intolerance, and a lower metabolic rate, which often accompanies weight gain or difficulty losing weight, along with other symptoms like dry skin and constipation.

So the description of a deficiency of thyroid secretion causing fatigue, cold intolerance, and a low metabolic rate matches hypothyroidism best. The other descriptions point to different conditions: excess thyroid secretion causes weight loss and heat intolerance (hyperthyroidism); Cushing's syndrome is due to excess cortisol; hyperprolactinemia involves high prolactin with reproductive symptoms.