Which condition is defined as fat accumulation in the liver without significant alcohol use?

• A. Hepatomegaly
• B. Jaundice
• C. NAFLD
• D. Gallstones

Answer: (C)

Non-alcoholic fatty liver disease is the condition described. It means fat builds up in the liver (hepatic steatosis) in someone who does not have significant alcohol consumption. This condition is commonly linked to metabolic factors like obesity, insulin resistance, type 2 diabetes, and dyslipidemia, and it can range from simple fat accumulation to inflammation and fibrosis if it progresses. Clinically, many people have no symptoms, and the liver may be enlarged. Diagnosis usually involves imaging findings of fatty change in the liver, sometimes with a biopsy, once substantial alcohol use has been ruled out. The other options aren’t about fat accumulating in the liver due to nonalcoholic causes—hepatomegaly is just an enlarged liver, jaundice is a yellowing from bilirubin, and gallstones are stones in the gallbladder.