Which statement about OTC medications is true?

• A. OTC medications require a prescription from a clinician.
• B. OTC medications are always safe and have no side effects.
• C. OTC medications do not interact with other drugs.
• D. OTC medications can interact with prescribed medications.

Answer: (D)

Over-the-counter medications are available without a prescription, but that doesn’t mean they’re without risk. The statement that OTC meds can interact with prescribed medications is true. OTC drugs can affect how a prescription drug works, change how it’s metabolized, or add new side effects. For example, taking an OTC pain reliever like ibuprofen with a prescription anticoagulant can raise bleeding risk; using acetaminophen with alcohol or with certain prescription drugs can increase liver toxicity; decongestants may raise blood pressure or interact with heart or antidepressant medications. Because of these possibilities, it’s important to review all medications—OTC and prescription—with a clinician or pharmacist to avoid interactions.